منابع مشابه
Drug metabolism in liver disease.
The liver is the most important site of drug metabolism and patients with liver disease might be expected to have a reduced capacity to metabolize drugs. The rates of elimination of extensively metabolized drugs such as the barbiturates, diazepam, tolbutamide, isoniazid, phenylbutazone, rifampicin, lignocaine, paracetamol, aminopyrine, antipyrine and pethidine have been measured in patients wit...
متن کاملConjugative drug metabolism in liver transplant patients.
L IVER TRANSPLANTATION is a therapeutic option for a number of liver diseases. I While the kinetics of several drugs are known to be altered in liver disease, very little is known about drug kinetics in liver transplant patients. Since liver transplant patients receive multiple drugs, a thorough understanding of the kinetics of these agents is essential for optimization of drug therapy in this ...
متن کاملSerotonin metabolism in liver disease.
Serotonin, (5-hydroxytryptamine, 5-HT, enteramine) is widely distributed in animal tissues and has been shown to have marked pharmacologic effects upon the gastrointestinal tract and cardiovascular system (1-4). Indirect evidence suggests that serotonin may play an important role in cerebral function, but, as yet, no direct connection has been established between serotonin and cerebral disease ...
متن کاملDrug therapies in liver disease.
The likelihood of a general physician encountering a patient with compensated and decompensated liver disease is increasing. This article provides an overview of pharmaceutical agents currently used in the management of cirrhosis and is designed to allow a better understanding of the rationale for using certain drugs in patients with often complex pathology.
متن کاملEvaluation the Efficiency of Paprika Drug on Liver Enzymes and Lipid Metabolism Changes Following Oxytetracycline Administration in Rats
Background: The aim of the present study was to investigate the effect of Paprika on the metabolism of lipid changes and hepatic enzyme activities following oxytetracycline administration in rats. Materials and Methods: A total of 36 adult male rats were divided into 6 equal groups and treated as follows. The control group (normal saline), fatty liver FL (oxytetracycline (Erfan drug Company) ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)31662-2